2019 – 2021

84. Marine alkaloids as bioactive agents against protozoal neglected tropical diseases and malaria

A. G. Tempone,* P. Pieper, S. E. T. Borborema, F. Thevenard, J. H. G. Lago, S. L. Croft,* E. A. Anderson*

Nat. Prod. Rep., 2021, Advance Article,

doi: https://doi.org/10.1039/D0NP00078G

83. Direct catalytic asymmetric synthesis of α-chiral bicyclo[1.1.1]pentanes

M. L. J. Wong, A. J. Sterling, J. J. Mousseau, F. Duarte,* E. A. Anderson*

Nat. Commun., 2021, 12, 1644,

doi: https://doi.org/10.1038/s41467-021-21936-4

Blog post: https://go.nature.com/3uWge10

82. Advances in polycyclization cascades in natural product synthesis

Y. Jiang,‡ R. E. McNamee,‡ P. J. Smith,‡ A. Sozanschi,‡ Z. Tong,‡ 

E. A. Anderson*

Chem. Soc. Rev., 2021, 50, 58–71 doi: https://doi.org/10.1039/D0CS00768D

81. Synthesis and Structure–Activity Relationship of Dehydrodieugenol B Neolignans against Trypanosoma cruzi

C. E. Sear, P. Pieper, M. Amaral, M. M. Romanelli, T. A. Costa-Silva, M. M. Haugland, J. A. Tate, J. H. G. Lago, A. G. Tempone*, E. A. Anderson*

ACS Infect. Dis., 2020, 6, 2872–2878, doi: 10.1021/acsinfecdis.0c00523

80. Site-Selective C–H Benzylation of Alkanes with N-Triftosylhydrazones Leading to Alkyl Aromatics

Z. Liu, S. Cao, W. Yu, J. Wu, F. Yi, E. A. Anderson*, X. Bi*

Chem, 2020, 6, 2110–2124, doi: 10.1016/j.chempr.2020.06.031

79. Copper-Catalyzed Intramolecular C–H Alkoxylation of Diaryltriazoles: Synthesis of Tricyclic Triazole Benzoxazines

X. Ma, H. Li, H. Xin, W. Du, E. A. Anderson*, X. Dong*, Y. Jiang*

Org. Lett., 2020, 22, 5320–5325 doi: 10.1021/acs.orglett.0c01517

78. Structure-activity relationship study of cytotoxic neolignan derivatives using multivariate analysis and computation-aided drug design

F. S. de Sousa, J. L. Baldim, R. A. Azevedo, C. R. Figueiredo, P. Pieper,

C. E. Sear, E. A. Anderson, J. H. G. Lago

Bioorg. Med. Chem. Lett., 2020, 30, 127349,

doi: 10.1016/j.bmcl.2020.127349

77. Synthesis of All-carbon Disubstituted Bicyclo[1.1.1]pentanes by Iron-Catalyzed Kumada Cross-Coupling

J. Nugent,‡ B. R. Shire,‡, D. F. J. Caputo, H. D. Pickford, F. Nightingale,

I. T. T. Houlsby, J. J. Mousseau,  E. A. Anderson

‡equal author contribution

Article: Angew. Chem. Int. Ed., 2020, 59, 11866–11870,

            doi: 10.1002/anie.202004090

Featured in: Org. Process Res. Dev., 2020, doi: 10.1021/acs.oprd.0c00344

76. Rationalizing the diverse reactivity of [1.1.1]propellane through 𝜎-𝜋-delocalization

A. J. Sterling, A. B. Dürr, R. C. Smith, E. A. Anderson, F. Duarte

Chem. Sci., 2020, 11, 4895–4903. doi: 10.1039/D0SC01386B

75. 2′-Alkynyl spin-labelling is a minimally perturbing tool for DNA structural analysis

J. S. Hardwick, M. M. Haugland, A. H. El-Sagheer, D. Ptchelkine, 

F. R. Beierlein,  A. N. Lane,  T. Brown,  J. E. Lovett,  E. A. Anderson

Nucleic Acids Research, 2020, 48, 2830–2840. doi: 10.1093/nar/gkaa086

74. A Modular, Enantioselective Synthesis of Resolvins D3, E1, and Hybrids

F. Urbitsch, B. L. Elbert, J. Llaveria, P. E. Streatfeild, E. A. Anderson

Org. Lett., 2020, 22, 1510–1515. doi: 10.1021/acs.orglett.0c00089

73. Enantioselective synthesis and anti-parasitic properties of aporphine natural products

P. Pieper, E. McHugh, M. Amaral, A. G.Tempone, E. A.Anderson

Tetrahedron., 2019, 76, 130814. doi: 10.1016/j.tet.2019.130814

72. Synthesis of Cyclic Alkenyl Dimethylsiloxanes from Alkynyl Benzyldimethylsilanes and Application in Polyene Synthesis

H. G. Gudmundsson, C. J. Kuper, D. Cornut, F. Urbitsch, B. L. Elbert,

E. A. Anderson

J. Org. Chem., 2019, 84, 14868-14882. doi: 10.1021/acs.joc.9b01664

71. Convergent Total Syntheses of (–)-Rubriflordilactone B and (–)-pseudo-Rubriflordilactone B

M. Mohammad, V. Chintalapudi, J. M. Carney, S. J. Mansfield, P. Sanderson, K. E. Christensen, E. A. Anderson

Angew. Chem. Int. Ed., 2019, 58, 18177–18181. 

doi: 10.1002/anie.201908917

70. Dehydrodieugenol B derivatives as antiparasitic agents: Synthesis and biological activity against Trypanosoma cruzi

D. D. Ferreira, F. S. Sousa, T. A. Costa-Silva, J. Q. Reimão, A. C. Torrecilhas, D. M. Johns, C. E. Sear, K. M. Honorio, J. H. G. Lago, E. A. Anderson, A. G. Tempone

Eur. J. Med. Chem., 2019, 176, 162-174. doi: 10.1016/j.ejmech.2019.05.001

69. A semi-synthetic neolignan derivative from dihydrodieugenol B selectively affects the bioenergetic system of Leishmania infantum and inhibits cell division

M. Amaral, F. S. de Sousa, T. A. Costa Silva, A. Jimenez G. Junior, N. N. Taniwaki, D. M. Johns, J. H. G. Lago, E. A. Anderson & A. G. Tempone

Scientific Reports, 2019, 6, 6114. doi: 10.1038/s41598-019-42273-z

68. Silver-Catalyzed C- to N-Center Remote Arene Migration

Y. Ning, A. Mekareeya, K. R. Babu, E. A. Anderson and X. Bi

ACS Catalysis, 2019, 9, 4203-4210. doi: 10.1021/acscatal.9b00500

67. A General Route to Bicyclo[1.1.1]pentanes through Photoredox Catalysis.

J. Nugent,* C. Arroniz,* B. R. Shire, A. J. Sterling, H. D. Pickford, M. L. J. Wong,  S. J. Mansfield, D. F. J. Caputo, B. Owen,  J. J. Mousseau, F. Duarte and E. A. Anderson

*equal author contribution

ACS Catalysis, 2019, 9, 9568-9574. doi: 10.1021/acscatal.9b03190

66. A General Copper-Catalyzed Synthesis of Ynamides from 1,2-Dichloroenamides.

S. J. Mansfield, R. C. Smith, J. R. J. Yong, O. L. Garry, and E. A. Anderson

Org. Lett., 2019, 21, 2918-2922. doi: 10.1021/acs.orglett.9b00971.

65. Synthesis of Enantioenriched α-Chiral Bicyclo[1.1.1]pentanes.

M. L. J. Wong, J. J. Mousseau, S. J. Mansfield and E. A. Anderson.

Org. Lett., 2019, 21, 2408-2411. doi: 10.1021/acs.orglett.9b00691.

64. Palladium-catalysed ligand-free reductive Heck cycloisomerisation of 1,6-en-α-chloro-enamides. 

Y. Hou, J. Ma, H. Yang, E. A. Anderson, A. Whiting and N. Wu. 

Chem. Commun., 2019, 55, 3733-3736. doi: 10.1039/C9CC00537D.

63. Direct Transformation of Terminal Alkynes into Amidines by a Silver-Catalyzed Four-Component Reaction. 

B. Liu, Y. Ning, M. Virelli, G. Zanoni, E. A. Anderson and X. Bi. 

J. Am. Chem. Soc., 2019, 141, 1593-1598. doi: 10.1021/jacs.8b11039.

62. Use of trifluoroacetaldehyde N-tfsylhydrazone as a trifluorodiazoethane surrogate and its synthetic applications.

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X. Zhang, Z. Liu, X. Yang, Y. Dong, M. Virelli, G. Zanoni, E. A. Anderson and X. Bi. 

Nature Commun., 2019, 10, 284. doi: 10.1038/s41467-018-08253-z.

61. Four Step Total Synthesis of an H3 Receptor Antagonist Using Only Tools Found in a Typical Teaching Laboratory.

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C. J. Smith, S. J. Mansfield, E. A. Anderson and J. W. Burton. 

J. Chem. Educ., 2019, 96, 137-142. doi: 10.1021/acs.jchemed.7b00982.